The most beautiful experience we can have is the mysterious.

It is the fundamental emotion that stands at the cradle of true art and true science.

— Albert Einstein

“Mystical” is an umbrella term for the profound personal revelations that someone might encounter. Either through psychedelics or other means.

Broadly speaking, a mystical experience is anything that is hard to comprehend or describe with rational or simple language. It is an experience that grants acquaintance with realities that are not accessible through mere sense perception, somatosensory modalities, or standard introspection. (source)

These mystical experiences can be produced by psilocybin, the naturally occurring psychedelic compound found in magic truffles.

Evidence has shown that psilocybin-occasioned mystical experiences, or psychedelic-induced peaks, reliably produce profound and transformative psychological experiences as well as notable and persisting increases in:

These mystical-type experiences have a lasting impact and are predictive of subsequent positive long-term outcomes after a high-dose session. 

In fact, in a 2006 Johns Hopkins study of psilocybin, 83% of the participants rated their psilocybin session as “among the five most personally and spiritually significant” of their lives…14 months later!

It goes without saying that the idea that a single experience can result in lasting beneficial effects in an individual’s attitudes or behavior is highly unusual if not unprecedented within the modern biomedical paradigm.

If you’re interested in a personalized psilocybin retreat, please have a look at the Truffle Transformation Experience.

Any man could, if he were so inclined, be the sculptor of his own brain.”

Santiago Ramón y Cajal, Nobel Prize-winning Spanish neuroscientist

Neuroplasticity, also known as brain plasticity or neural plasticity, is the ability of the brain to change continuously throughout your life. 

While it was believed for many decades that our brain was a nonrenewable organ and that brain cells were bestowed in a finite amount, dying slowly as we age. We now know that the brain can form new connections and pathways and change how its circuits are wired. 

During such changes, the brain engages in synaptic pruning, deleting the neural connections that are no longer necessary or useful, and strengthening the necessary ones. This process can be affected by inputs from your emotions, behaviors, experiences, and even thoughts.

For example, people suffering from depression or stress-related conditions, often have fewer connections, or fewer overall neurons, in specific parts of the brain.

There are two main types of neuroplasticity:

  • Structural neuroplasticity, in which the strength of the connections between neurons (or synapses) changes.
  • Functional neuroplasticity, in which the synapses change permanently due to learning and development, leading to changes to the actual structure of the brain.

Both types offer exciting capabilities and a study by researchers at the University of California showed that serotonergic psychedelics, including psilocin, increase neuritogenesis (new growth of neurons), spinogenesis (growth of spines on neurons), and synaptogenesis (the formation of synapses between neurons), thus promoting both forms of neuroplasticity.

This partially explains magic truffles’ therapeutic potential. Not only for the treatment of various neuropsychiatric disorders, but also by offering potential avenues for psychological change, such as “opening up the possibility to reinvent yourself and move away from the status quo or enabling you to overcome past traumatic events that evoke anxiety and stress.” (Christopher Bergland)

And that is, of course, great news.

Above: Functional connectivity of a normal brain (a) compared to a brain on psilocybin (b).

If you’re interested in a personalized psilocybin retreat, please have a look at the Truffle Transformation Experience.